Cef-3 Powder for Suspension 30ml

✔️ Uses of Cef-3 Powder for Suspension 30ml

• Treatment of Bacterial Infections

✔️ How does Cef-3 Powder for Suspension 30ml work?

Cefixime is included in Cef-3 Powder for Suspension 30ml. Cefixime's bactericidal activity is related to the suppression of cell wall production. As a result, the Cef-3 Powder for Suspension 30ml weakens and dissolves the bacterial cell wall, killing it. As a consequence, Cef-3 Powder for Suspension 30ml aids in the treatment of bacterial infections.

✔️ Side Effects of Cef-3 Powder for Suspension 30ml

• Stomach pain
• Dark or clay-colored stools
• Dizziness
• Excessive air or gas in the stomach
• Heartburn
• Chest pain
• Headache
• Fever
• Diarrhea
• Acid or sour stomach

✔️ Quick Suggestions:

• Your doctor has prescribed Cef-3 Powder for Suspension 30ml to cure your infection and improve your symptoms.
• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Take it with food to avoid an upset stomach.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• Avoid consuming alcohol while taking Cef-3 Powder for Suspension 30ml as it may cause increased side effects.
• Discontinue Cef-3 and inform your doctor immediately if you get a rash, itchy skin, swelling of your face and mouth, or difficulty in breathing.

✔️ Indication of Cef-3 Powder for Suspension 30ml

Cef-3 Powder for Suspension 30ml is an antibiotic medication. It is used in the treatment of bacterial infections of the urinary tract, lungs, throat, airways, tonsils, middle ear, and cervical/urethral infections. It is also used to treat typhoid fever.

✔️ Pharmacology

Cefixime is an oral semisynthetic third-generation cephalosporin antibiotic. It is bactericidal against a wide spectrum of gram-positive and gram-negative pathogens at easily obtained plasma concentrations. It kills germs by interfering with the development of the bacterial cell wall. It is particularly stable in the presence of the Beta-lactamase enzyme. As a result of the existence of beta-lactamases, many organisms resistant to penicillins and some cephalosporins may be vulnerable to Cefixime. It is absorbed 40% to 50% of the time, whether administered with or without food.

✔️ Dosage & Administration of Cef-3 Powder for Suspension 30ml

The recommended adult dose for various infections is as follows:

• Acute bronchitis and acute exacerbations of chronic bronchitis, otitis media, pharyngitis/tonsillitis, and uncomplicated urinary tract infections: 200 or 400 mg once daily or divided into two doses.
• Gonorrhea: 400 mg as a single dose.
• Typhoid fever: 20 mg/kg body weight daily, divided into two doses. The usual treatment duration is 7 days, but it can be extended up to 14 days based on the severity of the infection.

For children, the recommended doses are as follows:

• Children under 12 years: 8 mg/kg/day, given every 12 to 24 hours, if the weight is less than 50 kg. For convalescent oral therapy of serious infections, the dose can be increased up to 20 mg/kg/day.
• Children over 12 years: Same as the adult dose, either 200 or 400 mg once daily or divided into two doses.
• For children above 6 months, the dose is 8 mg/kg/day divided into 1 to 2 doses.
• For specific age groups: 6 months to 1 year: 75 mg daily, 1 to 4 years: 100 mg daily, and 5 to 10 years: 200 mg daily.
• Typhoid fever: 15 to 20 mg/kg/day, divided into two doses, for 7 to 14 days. The maximum daily dose should not exceed 400 mg.
• Safety and efficacy have not been established for children under 6 months of age.

In patients with renal impairment, dose reduction is necessary. If the creatinine clearance (CrCl) is less than 20 ml/min, the maximum daily dose should be limited to 200 mg.

✔️ Interaction

Cef-3 Powder for Suspension 30ml, which contains cefixime, may interact with certain vaccines such as BCG, cholera vaccine, and typhoid vaccine. It is advisable to consult with a healthcare professional regarding the timing and administration of these vaccines while taking cefixime.

Additionally, there may be interactions between Cef-3 Powder for Suspension 30ml and certain medications. For example, it may interact with anticoagulant medications like warfarin, which are used to thin the blood. Close monitoring of blood clotting parameters may be necessary when using both medications concurrently.

Another potential interaction is with anticonvulsant medications like carbamazepine, which are used to treat seizures. Cefixime may reduce the effectiveness of carbamazepine, and adjustments to the anticonvulsant medication may be needed under the guidance of a healthcare professional.

Regarding drug-food interactions, no specific interactions have been found or established for Cef-3 Powder for Suspension 30ml. However, it is always advisable to follow general guidelines for taking medications, such as taking them with or without food as directed by the healthcare provider.

Cef-3 Powder for Suspension 30ml may also interact with certain disease conditions. If you have colitis, which is inflammation of the colon's inner lining, caution should be exercised when using cefixime. It is important to inform your healthcare provider about your condition so they can determine the appropriateness of the medication.

Similarly, in patients with renal dysfunction or liver disease, the dose of Cef-3 Powder for Suspension 30ml may need adjustment. Close monitoring and appropriate dosage modifications should be done under the guidance of a healthcare professional.

Furthermore, individuals with seizure disorders should be cautious when using cefixime, as it may potentially trigger seizures or interact with anticonvulsant medications. Regular monitoring and adjustment of the treatment plan should be done in consultation with a healthcare professional.

✔️ Contraindications

Cefixime is a semisynthetic third-generation cephalosporin antibiotic that is designed for oral use. It exhibits bactericidal activity against a wide range of both gram-positive and gram-negative microorganisms. It achieves this by interfering with the production of the bacterial cell wall, ultimately leading to the death of the bacteria.

One notable characteristic of cefixime is its stability in the presence of the beta-lactamase enzyme. Beta-lactamases are enzymes produced by certain bacteria that can break down and inactivate certain types of antibiotics, such as penicillins and some cephalosporins. However, cefixime remains highly stable in the presence of beta-lactamases, allowing it to effectively combat bacteria that may be resistant to other antibiotics.

When taken orally, cefixime is absorbed by the body at a rate of approximately 40% to 50%, regardless of whether it is taken with or without meals. This means that the presence of food does not significantly affect its absorption.

Overall, cefixime is an effective antibiotic that can combat a broad spectrum of bacterial infections. Its stability against beta-lactamase enzymes and its oral formulation makes it a convenient and valuable treatment option for many patients.

✔️ Pregnancy & Lactation

Based on available data from published observational studies, case series, and case reports, there have been no established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes with the use of cephalosporins, including cefixime, in pregnant women. However, it is important to note that individual responses may vary, and caution should still be exercised.

Maternal gonorrhea, if left untreated during pregnancy, can lead to various complications such as preterm birth, low birth weight, chorioamnionitis (infection of the placental membranes), intrauterine growth restriction, small for gestational age, and premature rupture of membranes. Additionally, perinatal transmission of gonorrhea to the offspring can result in infant blindness, joint infections, and bloodstream infections.

Regarding lactation, there is limited information available on the presence of cefixime in human milk and its effects on breastfed infants or milk production. However, cefixime has been detected in animal milk. When a drug is present in animal milk, it is likely to also be present in human milk. In such cases, the developmental and health benefits of breastfeeding should be considered alongside the mother's clinical need for therapy and any potential adverse effects on the breastfed infant from the drug or the mother's underlying condition.

✔️ Precautions & Warnings

Cef-3 Powder for Suspension of 30ml has been associated with rare but serious hypersensitivity reactions, which can lead to shock and even death. If you experience any signs of a hypersensitive reaction, such as rash, itching, swelling, difficulty breathing, or severe dizziness, you should immediately stop using the medication and seek medical attention.

It is important not to take Cef-3 Powder for Suspension 30ml if you have a known allergy to cefixime or other cephalosporin antibiotics, or if you are allergic to any of the other ingredients in the medicine. Allergic reactions can be severe and potentially life-threatening.

Before taking Cef-3 Powder for Suspension 30ml, it is advisable to talk to your doctor if you have certain medical conditions. These include a history of seizures, liver or renal dysfunction, heart disorders, or inflammation of the colon's inner lining (colitis). Your doctor will evaluate the risks and benefits of using the medication in these situations and may need to make appropriate adjustments to the treatment plan.

If you are pregnant, planning for pregnancy, or breastfeeding, it is important to consult with your doctor before taking Cef-3 Powder for Suspension 30ml. The potential risks and benefits to both the mother and the baby need to be considered in these situations.

Cef-3 Powder for Suspension 30ml may cause dizziness as a side effect. Therefore, it is important to assess your alertness before driving or operating machinery. If you experience dizziness or any other side effects that impair your ability to drive safely, it is advisable to avoid driving until you feel alert and capable.

It is worth noting that Cef-3 Powder for Suspension 30ml may interact with certain tests, specifically those assessing glucose (sugar) levels in the urine. The medication can give unusual results in these tests. Therefore, it is important to inform your doctor that you are using Cef-3 Powder for Suspension 30ml before undergoing any tests to ensure an accurate interpretation of the results.

Always follow the advice and instructions of your healthcare provider regarding the use of Cef-3 Powder for Suspension 30ml, and inform them about any allergies, medical conditions, or medications you are currently taking or planning to take.

✔️ Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.